Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220455 | 0.89 | PTPN1 (0.62) | PTPN1PTPN6PTPN11SMN1; SMN2MEN1 | |
| SCHEMBL13947158 | 0.87 | SMN1; SMN2 (0.65) | SMN1; SMN2MEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL3214121 | 0.84 | MEN1 (0.61) | SMN1; SMN2MEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL14082987 | 0.83 | NPC1 (0.56) | PTPN1PTPN6PTPN11SMN1; SMN2MEN1 | |
| SCHEMBL3223614 | 0.82 | SMN1; SMN2 (0.54) | PTPN1SMN1; SMN2MEN1KMT2AKEAP1 | |
| SCHEMBL5934206 | 0.81 | TRPV1 (0.61) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14082451 | 0.81 | MEN1 (0.58) | PTPN1SMN1; SMN2MEN1KMT2AKEAP1 | |
| SCHEMBL3212017 | 0.81 | KMT2A (0.61) | PTPN1PTPN6PTPN11SMN1; SMN2MEN1 | |
| SCHEMBL14082275 | 0.81 | TRPV1 (0.63) | PTPN1PTPN6PTPN11SMN1; SMN2MEN1 | |
| SCHEMBL3222610 | 0.80 | MEN1 (0.62) | SMN1; SMN2MEN1KMT2AKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20070004701-A1 | Topoisomerase inhibitors | PROPHARMACON, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006022955-A2 | TOPOISOMERASE INHIBITORS | PROPHARMACON, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004701-A1 | Topoisomerase inhibitors | TOP1, TOP2A, TOP2B | PTPN1 2011/4885PTPN6 2040/4885PTPN11 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.