Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13486629 | 0.85 | HRH3 (0.72) | HRH3GAAADRA2AADRA1DHPGD | |
| SCHEMBL3193150 | 0.84 | HRH3 (1.00) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 | |
| SCHEMBL3192205 | 0.83 | HRH3 (1.00) | HRH3ADRA2AADRA1DCYP1A2CYP2D6 | |
| SCHEMBL3206922 | 0.83 | HRH3 (0.61) | HRH3GAAHDAC3HDAC4HDAC1 | |
| SCHEMBL4563222 | 0.81 | HRH3 (0.76) | HRH3ADRA2AADRA1D | |
| SCHEMBL15319511 | 0.79 | CA12 (0.56) | HDAC1HDAC6L3MBTL1 | |
| SCHEMBL3780865 | 0.79 | HDAC1 (0.59) | HDAC1HDAC6 | |
| SCHEMBL3996984 | 0.79 | SMN1; SMN2 (0.59) | HPGDHDAC1HDAC6KDM4ELMNA | |
| SCHEMBL3193396 | 0.79 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3193123 | 0.79 | HRH3 (1.00) | HRH3ADRA2AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | HRH3, HRH4, HRH1 | HRH3 1/4885GAA 1017/4885ADRA2A 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.