Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TTR | P02766 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28151908 | 0.78 | TSHR (0.50) | TSHRHSD17B10ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL13032567 | 0.76 | TSHR (0.44) | TSHRHSD17B10ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL11506834 | 0.74 | ALDH1A1 (0.50) | TSHRHSD17B10ALDH1A1CYP3A4RECQL | |
| SCHEMBL699157 | 0.73 | HSD17B10 (0.39) | TSHRHSD17B10ALDH1A1TTRCYP3A4 | |
| SCHEMBL3212678 | 0.73 | HSD17B10 (0.50) | TSHRHSD17B10ALDH1A1RECQLTHRB | |
| SCHEMBL12986726 | 0.72 | TSHR (0.36) | TSHRHSD17B10ALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL487689 | 0.70 | TSHR (0.41) | TSHRHSD17B10ALDH1A1ALOX15HIF1A | |
| SCHEMBL8441404 | 0.70 | TTR (0.52) | TSHRHSD17B10ALDH1A1TTRALOX15 | |
| SCHEMBL6798216 | 0.70 | TSHR (0.46) | TSHRHSD17B10ALDH1A1CYP3A4RECQL | |
| SCHEMBL1760716 | 0.69 | TSHR (0.57) | TSHRHSD17B10ALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056515-A1 | BENZIMIDAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2088861-A2 | BENZIMIDAZOLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008051533-A2 | BENZIMIDAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |
| US-5858695-A | SUBJECTING BILIRUBIN TO COEXIST WITH ASCORBATE OXIDASE AND A REACTION PROMOTER IN AQUEOUS MEDIUM TO THEREBY OXIDIZE THE BILIRUBIN, MEASURING THE CHANGE IN ABSORBANCE | KYOWA MEDEX CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0770688-A1 | Method of quantitative determination of bilirubin and a reagent therefor | KYOWA MEDEX CO., LTD. (JP) | 1997-05-02 | — | — | EP | disclosed |
| EP-0325472-A2 | Composition for testing periodontal diseases | SUNSTAR KABUSHIKI KAISHA (JP) | 1989-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056515-A1 | BENZIMIDAZOLE COMPOUNDS | HRH4, SSTR5, CNR1 | TSHR 168/4885HSD17B10 1266/4885ALDH1A1 1562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.