Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.72 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.65 |
| ▸ | EPOR | P19235 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KDM5A | P29375 | 1/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.57 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TLR4 | O00206 | 1/20 | 0.55 |
| ▸ | TLR2 | O60603 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213833 | 1.00 | BACE1 (0.72) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL10349069 | 0.95 | BACE1 (0.67) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL10349067 | 0.95 | BACE1 (0.67) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL3214950 | 0.92 | BACE1 (0.70) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL3214959 | 0.92 | BACE1 (0.70) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL10348278 | 0.89 | BACE1 (0.64) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL10348279 | 0.89 | BACE1 (0.64) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL7332640 | 0.87 | ALOX5 (0.68) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL8494290 | 0.87 | ALOX5 (0.68) | BACE1ALOX5PTGS1PTGS2EPOR | |
| SCHEMBL1206897 | 0.87 | ALOX5 (0.68) | BACE1ALOX5PTGS1PTGS2EPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | BACE1 1/4885ALOX5 1890/4885PTGS1 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.