Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | P2RY13 | Q9BPV8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490337 | 0.94 | NPC1 (0.44) | NPC1RAB9ASMYD3CHRNA7ALDH1A1 | |
| SCHEMBL3214906 | 0.94 | NPC1 (0.44) | NPC1RAB9ASMYD3CHRNA7ALDH1A1 | |
| SCHEMBL3202564 | 0.89 | NPC1 (0.48) | NPC1RAB9ACHRNA7ALDH1A1HPGD | |
| SCHEMBL13490431 | 0.88 | NPC1 (0.48) | NPC1RAB9ASMYD3CHRNA7ALDH1A1 | |
| SCHEMBL3199435 | 0.88 | NPC1 (0.48) | NPC1RAB9ACHRNA7ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3224048 | 0.87 | NPC1 (0.47) | NPC1RAB9ASMYD3CHRNA7ALDH1A1 | |
| SCHEMBL3210950 | 0.86 | NPC1 (0.46) | NPC1RAB9ASMYD3CHRNA7ALDH1A1 | |
| SCHEMBL3222668 | 0.86 | NPC1 (0.46) | NPC1RAB9ACHRNA7ALDH1A1HPGD | |
| SCHEMBL13490331 | 0.85 | NPC1 (0.46) | NPC1RAB9ACHRNA7ALDH1A1HPGD | |
| SCHEMBL3213404 | 0.85 | NPC1 (0.46) | NPC1RAB9ACHRNA7ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029615-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029615-A1 | BENZIMIDAZOLE DERIVATIVES | ACIN1, HAT1, CCNE1 | NPC1 3250/4885RAB9A 1662/4885ITK 1708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.