Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.80 |
| ▸ | MAPT | P10636 | 9/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.74 |
| ▸ | APP | P05067 | 4/20 | 0.72 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.68 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3214610 | 1.00 | BACE1 (0.80) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3204166 | 0.89 | BACE1 (1.00) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3204181 | 0.89 | BACE1 (1.00) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3209236 | 0.87 | JUN (0.77) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8686650 | 0.87 | MAPT (0.77) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7959387 | 0.87 | MAPT (0.77) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3209264 | 0.87 | JUN (0.77) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3210960 | 0.87 | APP (0.86) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3210991 | 0.87 | APP (0.86) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3200717 | 0.87 | BACE1 (0.80) | BACE1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371263-B2 | Protective effects of curcumin against hemorrhagic stroke injury | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371263-B2 | Protective effects of curcumin against hemorrhagic stroke injury | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150087705-A1 | Protective Effects of Curcumin Against Hemorrhagic Stroke Injury | AUGUSTA UNIVERSITY | 2015-03-26 | — | — | US | disclosed |
| US-20150087705-A1 | Protective Effects of Curcumin Against Hemorrhagic Stroke Injury | AUGUSTA UNIVERSITY | 2015-03-26 | — | — | US | disclosed |
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | BACE1 1/4885MAPT 8/4885ALDH1A1 253/4885 |
| US-20150087705-A1 | Protective Effects of Curcumin Against Hemorrhagic Stroke Injury | NFKBIA, AP1G1, NFRKB | BACE1 532/4885MAPT 1629/4885ALDH1A1 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.