Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | DNTT | P04053 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216611 | 1.00 | BACE1 (0.61) | BACE1ALOX5DNTTCAPN1CTSL | |
| SCHEMBL3217407 | 0.84 | BACE1 (0.69) | BACE1 | |
| SCHEMBL3217396 | 0.84 | BACE1 (0.69) | BACE1 | |
| SCHEMBL3222196 | 0.79 | RXRA (0.42) | BACE1 | |
| SCHEMBL1645750 | 0.76 | BACE1 (1.00) | BACE1ALOX5 | |
| SCHEMBL1645753 | 0.76 | BACE1 (1.00) | BACE1ALOX5 | |
| SCHEMBL13746120 | 0.75 | BACE1 (0.61) | BACE1ALOX5 | |
| SCHEMBL1646989 | 0.74 | BACE1 (0.73) | BACE1ALOX5 | |
| SCHEMBL1646127 | 0.74 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1646124 | 0.74 | BACE1 (1.00) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | BACE1 1/4885ALOX5 1890/4885DNTT 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.