Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3205372 | 0.94 | ABCG2 (0.42) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL3215132 | 0.87 | KMT2A (0.49) | SMN1; SMN2MAPK1NPC1RAB9ATSHR | |
| SCHEMBL3129788 | 0.84 | HTT (0.51) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL3202700 | 0.76 | LMNA (0.40) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL3123192 | 0.75 | PDE4A (0.48) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL3129124 | 0.75 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL3738587 | 0.75 | MAPT (0.64) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL4117088 | 0.74 | KMT2A (0.72) | SMN1; SMN2MAPK1NPC1RAB9ATP53 | |
| SCHEMBL11238694 | 0.73 | TSHR (0.61) | SMN1; SMN2MAPK1NPC1RAB9ATSHR | |
| SCHEMBL30675569 | 0.72 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | SMN1; SMN2 3703/4885MAPK1 1371/4885NPC1 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.