Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 18/20 | 0.86 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.44 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asp-4058 SCHEMBL29646278 | 1.00 | S1PR1 (0.86) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| Asp-4058 SCHEMBL1798268 | 1.00 | S1PR1 (0.86) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| Asp-4058 SCHEMBL3195457 | 1.00 | S1PR1 (0.86) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| Asp-4058 SCHEMBL3219834 | 0.99 | S1PR1 (0.84) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| Asp-4058 SCHEMBL22729322 | 0.99 | S1PR1 (0.84) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| Asp-4058 SCHEMBL3216963 | 0.99 | S1PR1 (0.84) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| SCHEMBL12619225 | 0.93 | S1PR1 (0.75) | S1PR1PSMD11DYRK3MAP4K4ERBB2 | |
| SCHEMBL12619235 | 0.90 | S1PR1 (0.70) | S1PR1PSMD11S1PR3S1PR5 | |
| SCHEMBL12619155 | 0.89 | S1PR1 (0.68) | S1PR1PSMD11MAP4K4MINK1S1PR3 | |
| SCHEMBL3207522 | 0.89 | S1PR1 (0.68) | S1PR1PSMD11MAP4K4MINK1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210113529-A1 | MEDICINE FOR PREVENTING OR TREATING OPHTHALMIC DISEASE ASSOCIATED WITH ENHANCED INTRAOCULAR NEOVASCULARIZATION AND/OR INTRAOCULAR VASCULAR PERMEABILITY | KYOTO UNIVERSITY (JP) | 2021-04-22 | — | — | US | claimed |
| EP-3747471-A1 | MEDICINE FOR PREVENTING OR TREATING OPHTHALMIC DISEASE ASSOCIATED WITH ENHANCED INTRAOCULAR NEOVASCULARIZATION AND/OR INTRAOCULAR VASCULAR PERMEABILITY | Kyoto University (JP) | 2020-12-09 | — | — | EP | claimed |
| EP-2990055-B1 | COMPOSITION COMPRISING A SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 AGONIST FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR FOR SHRINKING IT | UNIV KYOTO (JP) | 2019-06-05 | — | — | EP | claimed |
| US-9629834-B2 | Medicinal composition for inhibiting formation and/or enlargement of cerebral aneurysm or shrinking same | KYOTO UNIVERSITY (JP) | 2017-04-25 | — | — | US | claimed |
| US-20160113917-A1 | MEDICINAL COMPOSITION FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR SHRINKING SAME | KYOTO UNIVERSITY (JP) | 2016-04-28 | — | — | US | claimed |
| EP-2990055-A1 | MEDICINAL COMPOSITION FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR SHRINKING SAME | Kyoto University (JP) | 2016-03-02 | — | — | EP | claimed |
| EP-2003132-B1 | Oxadiazole derivatives as S1P1 agonists | ASTELLAS PHARMA INC (JP) | 2014-03-05 | — | — | EP | claimed |
| US-7678820-B2 | Hetero compound | ASTELLAS PHARMA INC. (JP) | 2010-03-16 | — | — | US | claimed |
| US-20090076070-A1 | HETERO COMPOUND | ASTELLAS PHARMA INC. (JP) | 2009-03-19 | — | — | US | claimed |
| WO-2025083549-A1 | METHODS AND COMBINATIONS OF INHIBITORS OF IL-23 PATHWAY AND MODULATORS OF S1P SIGNALING PATHWAY FOR THE TREATMENT OF AUTOIMMUNE DISORDERS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2025-04-24 | — | — | WO | disclosed |
| EP-3723801-B9 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR | BIORA THERAPEUTICS INC (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-3723801-B9 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR | BIORA THERAPEUTICS INC (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-3723801-B1 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR | BIORA THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-3723801-B1 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR | BIORA THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-20100168159-A1 | HETERO COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-20100168159-A1 | HETERO COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-7678820-B2 | Hetero compound | ASTELLAS PHARMA INC. (JP) | 2010-03-16 | — | — | US | disclosed |
| US-7678820-B2 | Hetero compound | ASTELLAS PHARMA INC. (JP) | 2010-03-16 | — | — | US | disclosed |
| US-20090076070-A1 | HETERO COMPOUND | ASTELLAS PHARMA INC. (JP) | 2009-03-19 | — | — | US | disclosed |
| US-20090076070-A1 | HETERO COMPOUND | ASTELLAS PHARMA INC. (JP) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168159-A1 | HETERO COMPOUND | S1PR1, ENPP2, LPAR1 | S1PR1 1/4885PSMD11 2632/4885DYRK3 2911/4885 |
| US-20090076070-A1 | HETERO COMPOUND | S1PR1, ENPP2, LPAR1 | S1PR1 1/4885PSMD11 2632/4885DYRK3 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.