Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Diethyl Phthalate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CDC25B | P30305 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethyl Phthalate SCHEMBL1134636 | 0.87 | TSHR (0.56) | TSHRALDH1A1HSD17B10KDM4EKMT2A | |
| Dibutyl Phthalate SCHEMBL18094424 | 0.85 | TSHR (0.69) | TSHRALDH1A1HSD17B10KDM4EKMT2A | |
| Diethyl Phthalate SCHEMBL27714821 | 0.83 | TSHR (0.81) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL28775845 | 0.83 | TSHR (0.95) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL19252611 | 0.83 | TSHR (0.95) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL28168029 | 0.81 | TSHR (0.91) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL29404255 | 0.81 | TSHR (1.00) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL22296 | 0.81 | TSHR (1.00) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL5306972 | 0.81 | TSHR (1.00) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL27773128 | 0.80 | TSHR (0.81) | TSHRALDH1A1HSD17B10CDC25BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591048-B1 | MATERIAL BASED ON CELLULOSE ACETATE WITH PLASTICISERS AND MANUFACTURED ARTICLE PRODUCED THEREWITH | MAZZUCCHELLI 1849 SPA (IT) | 2017-03-29 | — | — | EP | disclosed |
| CN-103097448-B | Material based on cellulose acetate with a plasticizer and article made with this material | MAZZUCCHELLI 1849 S.P.A. (IT) | 2016-01-20 | — | — | CN | disclosed |
| US-8783860-B2 | Material based on cellulose acetate with plasticisers and manufactured article produced therewith | MAZZUCCHELLI 1849 S.P.A. (IT) | 2014-07-22 | — | — | US | disclosed |
| US-20130169921-A1 | MATERIAL BASED ON CELLULOSE ACETATE WITH PLASTICISERS AND MANUFACTURED ARTICLE PRODUCED THEREWITH | MAZZUCCHELLI 1849 S.P.A. (IT) | 2013-07-04 | — | — | US | disclosed |
| EP-2591048-A1 | MATERIAL BASED ON CELLULOSE ACETATE WITH PLASTICISERS AND MANUFACTURED ARTICLE PRODUCED THEREWITH | Mazzucchelli 1849 S.p.A. (IT) | 2013-05-15 | — | — | EP | disclosed |
| CN-103097448-A | Material based on cellulose acetate with a plasticizer and article made with this material | MAZZUCCHELLI 1849 SPA | 2013-05-08 | — | — | CN | disclosed |
| WO-2012004727-A1 | MATERIAL BASED ON CELLULOSE ACETATE WITH PLASTICISERS AND MANUFACTURED ARTICLE PRODUCED THEREWITH | MAZZUCCHELLI 1849 S.P.A. (IT) | 2012-01-12 | — | — | WO | disclosed |