Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 15/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 8/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089892 | 0.86 | PTGDR2 (0.38) | PTGDR2PTGDRCYP2C9TBXA2RCYP3A4 | |
| SCHEMBL204984 | 0.86 | PTGDR2 (0.38) | PTGDR2PTGDRCYP2C9TBXA2RCYP3A4 | |
| SCHEMBL3088635 | 0.86 | PTGDR2 (0.54) | PTGDR2PTGDRCYP2C9TBXA2RCYP3A4 | |
| SCHEMBL3091564 | 0.86 | PTGDR2 (0.39) | PTGDR2PTGDRCYP2C9TBXA2RCYP3A4 | |
| SCHEMBL3085509 | 0.83 | AGTR2 (0.39) | PTGDR2PTGDRCYP2C9AGTR2 | |
| SCHEMBL3090539 | 0.82 | PTGDR2 (0.38) | PTGDR2PTGDRCYP2C9TBXA2R | |
| SCHEMBL3084890 | 0.81 | PTGDR2 (0.36) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL3099698 | 0.80 | PTGDR2 (0.34) | PTGDR2PTGDRCYP2C9TBXA2RAGTR2 | |
| SCHEMBL3084609 | 0.79 | PTGDR2 (0.37) | PTGDR2PTGDRCYP2C9AGTR2 | |
| SCHEMBL3083460 | 0.78 | PTGDR2 (0.39) | PTGDR2PTGDRCYP2C9TBXA2RCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394819-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100234415-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234415-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | PTGER2, PTGDR2, PTGDR | PTGDR2 2/4885PTGDR 3/4885CYP2C9 1320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.