Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 8/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 5/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | ELANE | P08246 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.45 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.45 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.45 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.45 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.45 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222713 | 1.00 | LONP1 (0.55) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3222744 | 1.00 | LONP1 (0.55) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3217980 | 0.93 | ABCG2 (0.48) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3217992 | 0.93 | ABCG2 (0.48) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3218000 | 0.93 | ABCG2 (0.48) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3213559 | 0.90 | ABCG2 (0.46) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3213523 | 0.90 | ABCG2 (0.46) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3213517 | 0.90 | ABCG2 (0.46) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3210500 | 0.89 | LONP1 (0.51) | LONP1ABCG2CTSBCTSSELANE | |
| SCHEMBL3210516 | 0.89 | LONP1 (0.51) | LONP1ABCG2CTSBCTSSELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303547-A1 | HCV Protease Inhibitors and Uses Thereof | ABBVIE INC (US) | 2013-11-14 | — | — | US | disclosed |
| US-8497275-B2 | HCV protease inhibitors and uses thereof | ABBVIE INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-20100029686-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2008074035-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303547-A1 | HCV Protease Inhibitors and Uses Thereof | SERPINB1, PEPD, PREP | LONP1 375/4885ABCG2 515/4885CTSB 38/4885 |
| US-20100029686-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | SERPINB1, PEPD, PREP | LONP1 375/4885ABCG2 515/4885CTSB 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.