Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225653 | 0.89 | SCN9A (0.46) | SCN9ASLC6A2SLC6A3SLC6A4HTR3A | |
| SCHEMBL3234471 | 0.89 | SLC6A2 (0.57) | SCN9ASLC6A2SLC6A3SLC6A4HTR3A | |
| SCHEMBL3235921 | 0.85 | SCN9A (0.45) | SCN9ASLC6A2SLC6A3SLC6A4HTR3A | |
| SCHEMBL3479672 | 0.85 | SCN9A (0.45) | SCN9ASLC6A2SLC6A3SLC6A4HTR3A | |
| SCHEMBL3230133 | 0.85 | SCN9A (0.51) | SCN9ASLC6A2SLC6A3SLC6A4HTR3A | |
| SCHEMBL3479582 | 0.84 | SLC6A2 (0.55) | SCN9ASLC6A2SLC6A3SLC6A4HTR3A | |
| SCHEMBL3231435 | 0.84 | SCN9A (0.44) | SCN9ASLC6A2SLC6A3SLC6A4TERT | |
| SCHEMBL3233080 | 0.84 | SCN9A (0.45) | SCN9ASLC6A2SLC6A3SLC6A4HTR6 | |
| SCHEMBL3230004 | 0.84 | SCN9A (0.45) | SCN9ASLC6A2SLC6A3SLC6A4DRD2 | |
| SCHEMBL3225188 | 0.84 | SCN9A (0.45) | SCN9ASLC6A2SLC6A3SLC6A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146722-A1 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008141081-A1 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2008-11-20 | — | — | WO | disclosed |