Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225091 | 0.91 | SCN9A (0.43) | SCN9ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3234883 | 0.89 | SCN9A (0.46) | SCN9ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3231895 | 0.89 | SCN9A (0.48) | SCN9ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3225188 | 0.88 | SCN9A (0.45) | SCN9ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3231435 | 0.87 | SCN9A (0.44) | SCN9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3231537 | 0.86 | SCN9A (0.44) | SCN9ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3237056 | 0.86 | SCN9A (0.50) | SCN9ASLC6A2SLC6A4SLC6A3CCNA2 | |
| SCHEMBL3479579 | 0.85 | SCN9A (0.45) | SCN9ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL3221969 | 0.84 | SCN9A (0.48) | SCN9ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3223059 | 0.84 | SCN9A (0.45) | SCN9ASLC6A2SLC6A4SLC6A3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146722-A1 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008141081-A1 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2008-11-20 | — | — | WO | disclosed |