Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218359 | 0.89 | HDAC1 (0.48) | KMT2ALMNAMAPTMEN1KDM4E | |
| SCHEMBL3199806 | 0.81 | PTPN1 (0.67) | KMT2ALMNAMAPTMEN1KDM4E | |
| SCHEMBL14344520 | 0.80 | HTT (0.54) | KMT2AMEN1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL775158 | 0.79 | ABL1 (0.61) | KMT2ALMNAMAPTMEN1KDM4E | |
| SCHEMBL774860 | 0.78 | RAB9A (0.64) | KMT2ALMNAMAPTMEN1KDM4E | |
| SCHEMBL3618498 | 0.77 | KMT2A (0.53) | KMT2AMEN1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL3224360 | 0.77 | RAB9A (0.71) | KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3208598 | 0.76 | POLB (0.70) | KMT2ALMNAMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL777653 | 0.75 | MEN1 (0.64) | KMT2ALMNAMAPTMEN1KDM4E | |
| SCHEMBL774680 | 0.75 | DEGS1 (0.48) | KMT2ALMNAMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |