SCHEMBL3223737

SCHEMBL3223737

CCCCc1oc2ccccc2c1C(=O)c1ccc(O)c(I)c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EYA3 Q99504 4/20 0.81
PTPN1 P18031 1/20 0.71
THRA P10827 3/20 0.66
THRB P10828 3/20 0.66
TTR P02766 2/20 0.65
KDM5A P29375 7/20 0.65
KDM4A O75164 3/20 0.65
ING2 Q9H160 1/20 0.65
SIRT3 Q9NTG7 4/20 0.63
ABCB11 O95342 2/20 0.62
ADRA2A P08913 2/20 0.62
DRD1 P21728 2/20 0.62
SLC6A2 P23975 2/20 0.62
OPRM1 P35372 2/20 0.62
DRD3 P35462 2/20 0.62
SLC6A3 Q01959 2/20 0.62
HRH3 Q9Y5N1 2/20 0.62
MEN1 O00255 1/20 0.62
BIRC5 O15392 1/20 0.62
LMNA P02545 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6335384 0.90 EYA3 (1.00) EYA3PTPN1THRATHRBTTR
SCHEMBL1287675 0.88 EYA3 (0.79) EYA3PTPN1THRBTTRABCB11
SCHEMBL11851343 0.87 EYA3 (0.72) EYA3PTPN1THRATHRBTTR
SCHEMBL11844336 0.86 TTR (0.79) EYA3PTPN1THRATHRBTTR
SCHEMBL25387500 0.86 EYA3 (0.60) EYA3PTPN1THRATHRBTTR
SCHEMBL25047095 0.85 EYA3 (0.91) EYA3PTPN1THRATHRBTTR
SCHEMBL25390721 0.85 EYA3 (0.91) EYA3PTPN1THRATHRBTTR
Cyanide SCHEMBL28104486 0.85 EYA3 (0.74) EYA3PTPN1THRBTTRABCB11
SCHEMBL31314614 0.84 EYA3 (0.79) EYA3PTPN1THRATHRBTTR
SCHEMBL31314615 0.84 EYA3 (0.79) EYA3PTPN1THRATHRBTTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US claimed
EP-1404413-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2004-04-07 EP claimed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP claimed
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
WO-2002089917-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2002-11-14 WO claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
EP-0584186-B1 RECEPTOR LIGANDS KAROBIO AB (SE) 1996-08-21 EP claimed
EP-0584186-A1 RECEPTOR LIGANDS. KAROBIO AB (SE) 1994-03-02 EP claimed
WO-1992020331-A1 RECEPTOR LIGANDS KAROBIO AKTIEBOLAG (SE) 1992-11-26 WO claimed
WO-2023149549-A1 NOVEL PHARMACEUTICAL COMPOSITION 国立大学法人富山大学 2023-08-10 WO disclosed
US-9757352-B2 Parenteral dosage form of amiodarone SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) 2017-09-12 US disclosed
US-4791137-A Pharmaceutical and veterinary compositions for the treatment of ischemic cardiac disorders SANOFI (FR) 1988-12-13 US disclosed
US-4661514-A ANTIARRHYTHMIA AGENTS SANOFI (FR) 1987-04-28 US disclosed
US-4575513-A ANTIARRHYTHMIA, ANGINA PECTORIS SANOFI (FR) 1986-03-11 US disclosed