Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223803 | 1.00 | CYP1A2 (0.49) | CYP1A2CYP2C19CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28535502 | 0.79 | MEN1 (0.63) | KMT2ARAB9AMEN1NPC1LMNA | |
| SCHEMBL25383671 | 0.77 | KMT2A (0.53) | CYP1A2CYP2C19CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10025752 | 0.77 | MAPT (0.43) | CYP1A2CYP2C19CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3219704 | 0.77 | KCNH2 (0.42) | CYP1A2CYP2C19CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31052662 | 0.75 | KMT2A (0.56) | CYP1A2CYP2C19CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3294386 | 0.74 | TSHR (0.46) | CYP1A2CYP2C19CYP3A4KMT2AMEN1 | |
| SCHEMBL25382805 | 0.74 | CYP1A2 (0.45) | CYP1A2CYP2C19CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8791171 | 0.73 | RAB9A (0.44) | CYP1A2CYP3A4KMT2ARAB9AMEN1 | |
| SCHEMBL2482068 | 0.73 | KDM4E (0.59) | KMT2AMEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662193-B2 | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins | AC IMMUNE SA (CH) | 2020-05-26 | — | — | US | disclosed |
| EP-2328891-B1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2017-04-05 | — | — | EP | disclosed |
| US-20170002005-A1 | Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins | LIFE MOLECULAR IMAGING LIMITED (GB) | 2017-01-05 | — | — | US | disclosed |
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | disclosed |
| WO-2015110263-A1 | CARBAZOLE AND CARBOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS, TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH AMYLOID OR AMYOLID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2015-07-30 | — | — | WO | disclosed |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2014-10-02 | — | — | US | disclosed |
| US-8193363-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2012-06-05 | — | — | US | disclosed |
| WO-2010024769-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662193-B2 | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins | APP, BACE1, PSEN1 | CYP1A2 974/4885CYP2C19 3235/4885CYP3A4 1220/4885 |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | APP, PSEN1, PSEN2 | CYP1A2 2495/4885CYP2C19 3789/4885CYP3A4 2743/4885 |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | APP, PSEN1, PSEN2 | CYP1A2 2495/4885CYP2C19 3789/4885CYP3A4 2743/4885 |
| US-20170002005-A1 | Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins | APP, BACE1, PSEN1 | CYP1A2 974/4885CYP2C19 3235/4885CYP3A4 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.