Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cyclopropane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL5933717 | 1.00 | — | — | |
| Alcohol SCHEMBL27972143 | 1.00 | ALDH1A1 (0.67) | — | |
| Cyclopentane SCHEMBL9633004 | 1.00 | ALDH1A1 (0.67) | — | |
| Cyclohexane SCHEMBL12482623 | 1.00 | ALDH1A1 (0.67) | — | |
| Cycloheptane SCHEMBL14721149 | 1.00 | ALDH1A1 (0.67) | — | |
| Alcohol SCHEMBL3968617 | 1.00 | ALDH1A1 (0.67) | — | |
| Cyclohexane SCHEMBL9633835 | 1.00 | ALDH1A1 (0.67) | — | |
| Cyclohexane SCHEMBL959934 | 1.00 | — | — | |
| Cyclopropane SCHEMBL1923331 | 1.00 | — | — | |
| Cyclopentane SCHEMBL5158267 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456207-B | Method for preparing chiral beta-aryl ketone compound through visible light/nickel catalytic asymmetric beta-arylation reaction | 山东大学 | 2023-05-30 | — | — | CN | claimed |
| CN-114456207-A | Method for preparing chiral beta-aryl ketone compound by visible light/nickel catalysis asymmetric beta-arylation reaction | 山东大学 | 2022-05-10 | — | — | CN | claimed |
| CN-111925319-B | Synthesis method of gamma-ketosulfone compound | 台州学院 | 2022-02-01 | — | — | CN | claimed |
| CN-113444037-A | Green synthesis method of nicotinic acid ester compound based on nonmetal condition | 安阳师范学院 | 2021-09-28 | — | — | CN | claimed |
| CN-114560753-B | Process for preparing hydroxy epoxy analogues | 深圳千越生物科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| US-20240025870-A1 | PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Synaptogenix, Inc. (US) | 2024-01-25 | — | — | US | disclosed |
| US-11820745-B2 | PKC-activating compounds for the treatment of neurodegenerative diseases | Synaptogenix, Inc. (US) | 2023-11-21 | — | — | US | disclosed |
| US-20230235378-A1 | LZHEIMER'S DISEASE-SPECIFIC ALTERATIONS OF PROTEIN KINASE C EPSILON (PKC-EPSILON PROTEIN LEVELS | WEST VIRGINIA UNIVERSITY | 2023-07-27 | — | — | US | disclosed |
| CN-114456207-B | Method for preparing chiral beta-aryl ketone compound through visible light/nickel catalytic asymmetric beta-arylation reaction | 山东大学 | 2023-05-30 | — | — | CN | disclosed |
| CN-114456207-B | Method for preparing chiral beta-aryl ketone compound through visible light/nickel catalytic asymmetric beta-arylation reaction | 山东大学 | 2023-05-30 | — | — | CN | disclosed |
| US-20220356161-A1 | PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Synaptogenix, Inc. (US) | 2022-11-10 | — | — | US | disclosed |
| US-11390596-B2 | PKC-activating compounds for the treatment of neurodegenerative diseases | Synaptogenix, Inc. (US) | 2022-07-19 | — | — | US | disclosed |
| US-5916986-A | Coating composition for coatings resistant to environmental etch | BASF CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |
| WO-1999010331-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-03-04 | — | — | WO | disclosed |
| US-5635302-A | CURED COATING COMPRISING STERICALLY HINDERED MONOMER AND ETHYLENICALLY UNSATURATED COMONOMER | BASF CORPORATION (US) | 1997-06-03 | — | — | US | disclosed |
| US-4567290-A | Leukotriene analogues | RESEARCH CORPORATION (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0094963-A4 | LEUKOTRIENE ANALOGUES. | RESEARCH CORP (US) | 1984-09-19 | — | — | EP | disclosed |
| US-4442099-A | Leukotriene analogues | RESEARCH CORPORATION (US) | 1984-04-10 | — | — | US | disclosed |
| EP-0094963-A1 | LEUKOTRIENE ANALOGUES | Research Corporation (US) | 1983-11-30 | — | — | EP | disclosed |
| WO-1983001897-A1 | LEUKOTRIENE ANALOGUES | RESEARCH CORP (US) | 1983-06-09 | — | — | WO | disclosed |