Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 7/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 7/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3285768 | 0.87 | CHEK1 (0.42) | CHEK1AURKATRPA1IRAK4MAP3K7 | |
| SCHEMBL31618054 | 0.85 | CHEK1 (0.40) | CHEK1AURKATRPA1IRAK4PRKD3 | |
| SCHEMBL13005543 | 0.85 | CHEK1 (0.40) | CHEK1AURKATRPA1IRAK4PRKD3 | |
| SCHEMBL3372101 | 0.80 | CHEK1 (0.40) | CHEK1AURKAMAP3K7TAB1AKT1 | |
| SCHEMBL20195284 | 0.77 | CHEK1 (0.49) | CHEK1AURKATRPA1IRAK4MAP3K7 | |
| SCHEMBL4780230 | 0.75 | CHEK1 (0.56) | CHEK1AURKATRPA1IRAK4MAP3K7 | |
| SCHEMBL16765141 | 0.74 | CHEK1 (0.49) | CHEK1AURKATRPA1IRAK4MAP3K7 | |
| SCHEMBL24345183 | 0.73 | CHEK1 (0.58) | CHEK1AURKATRPA1IRAK4MAP3K7 | |
| SCHEMBL27804119 | 0.72 | CHEK1 (0.46) | CHEK1TRPA1IRAK4MAP3K7TAB1 | |
| SCHEMBL2783376 | 0.72 | CHEK1 (0.53) | CHEK1AURKATRPA1IRAK4MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015637-A1 | NEW ANTIVIRAL MODIFIED NUCLEOSIDES | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015637-A1 | NEW ANTIVIRAL MODIFIED NUCLEOSIDES | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |