Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | STK3 | Q13188 | 4/20 | 0.36 |
| ▸ | STK4 | Q13043 | 3/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780230 | 0.86 | CHEK1 (0.56) | CHEK1CYP3A4CYP2C19AURKAIRAK4 | |
| SCHEMBL16765811 | 0.83 | CHEK1 (0.49) | CHEK1AURKAIRAK4TRPA1STK3 | |
| SCHEMBL24345183 | 0.81 | CHEK1 (0.58) | CHEK1AURKAIRAK4TRPA1STK3 | |
| SCHEMBL20195284 | 0.80 | CHEK1 (0.49) | CHEK1AURKAIRAK4TRPA1STK3 | |
| SCHEMBL3236479 | 0.79 | CHEK1 (0.56) | CHEK1AURKAIRAK4STK3STK4 | |
| SCHEMBL16765141 | 0.76 | CHEK1 (0.49) | CHEK1AURKAIRAK4TRPA1STK3 | |
| SCHEMBL12065776 | 0.76 | CHEK1 (0.49) | CHEK1CYP3A4CYP2C19AURKAIRAK4 | |
| SCHEMBL3285768 | 0.76 | CHEK1 (0.42) | CHEK1AURKAIRAK4TRPA1STK3 | |
| SCHEMBL16765827 | 0.75 | CHEK1 (0.51) | CHEK1CHUKROCK2CSNK2A1ROCK1 | |
| SCHEMBL2696119 | 0.75 | LRRK2 (0.50) | CHEK1AURKASTK3CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010066629-A2 | NOVEL AZAINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010066629-A2 | NOVEL AZAINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-17 | — | — | WO | disclosed |
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | DILLON MICHAEL PATRICK | 2010-06-10 | — | — | US | disclosed |
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | DILLON MICHAEL PATRICK | 2010-06-10 | — | — | US | disclosed |
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | DILLON MICHAEL PATRICK | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | P2RX3, P2RX2, P2RX7 | CHEK1 4153/4885CYP3A4 1815/4885CYP2C19 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.