SCHEMBL3226523

SCHEMBL3226523

COCCn1c(SC)nc(-c2ccc(F)cc2)c1-c1ccnc(N[C@H](C)CO)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 1.00
MAPK10 P53779 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3226361 1.00 MAPK14 (1.00) MAPK14MAPK10
SCHEMBL3234513 1.00 MAPK14 (1.00) MAPK14MAPK10
SCHEMBL2847757 0.91 MAPK14 (0.84) MAPK14MAPK10
SCHEMBL2849393 0.90 MAPK14 (0.82) MAPK14MAPK10
SCHEMBL3231555 0.90 MAPK14 (0.82) MAPK14MAPK10
SCHEMBL4618666 0.90 MAPK14 (0.82) MAPK14MAPK10
SCHEMBL3223244 0.87 MAPK14 (1.00) MAPK14MAPK10
SCHEMBL2843699 0.86 MAPK14 (1.00) MAPK14MAPK10
SCHEMBL2845705 0.86 MAPK14 (0.75) MAPK14MAPK10
SCHEMBL3109130 0.85 MAPK14 (0.82) MAPK14MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100069436-A1 IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT Merckle (DE) 2010-03-18 US claimed
EP-1894925-A1 Imidazole compounds having an antiinflammatory effect MERCKLE GMBH (DE) 2008-03-05 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069436-A1 IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT MIF, TNF, IL1B MAPK14 2368/4885MAPK10 2074/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.