Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 15/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 15/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 15/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 13/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 13/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.33 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711243 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711527 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711255 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL20587813 | 0.79 | CHRNB2 (0.50) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL12926722 | 0.78 | CHRNB2 (0.53) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL3240417 | 0.77 | CHRNB2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL26694865 | 0.77 | CHRNB2 (0.49) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL3239629 | 0.77 | CHRNB2 (0.45) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL3239097 | 0.76 | CHRNB2 (0.75) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| Isoquinuclidine SCHEMBL3913758 | 0.74 | CHRNB2 (0.33) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |