Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 10/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225379 | 0.91 | TNNI3K (0.60) | TNNI3KEGFRS1PR1ROCK1MEN1 | |
| SCHEMBL3227005 | 0.87 | TNNI3K (0.57) | TNNI3KEGFRS1PR1ROCK1MEN1 | |
| SCHEMBL3226072 | 0.85 | EGFR (0.56) | EGFRERBB3S1PR1MEN1KMT2A | |
| SCHEMBL3230965 | 0.83 | S1PR1 (0.56) | EGFRERBB3S1PR1MEN1ALDH1A1 | |
| SCHEMBL3231547 | 0.83 | EGFR (0.60) | TNNI3KEGFRERBB3S1PR1MEN1 | |
| SCHEMBL3228067 | 0.83 | EGFR (0.58) | EGFRERBB3S1PR1MEN1KMT2A | |
| SCHEMBL3222813 | 0.83 | EGFR (0.64) | EGFRERBB3S1PR1MEN1ALDH1A1 | |
| SCHEMBL3224951 | 0.82 | S1PR1 (0.62) | EGFRERBB3S1PR1CDK9MEN1 | |
| SCHEMBL3232976 | 0.82 | SMN1; SMN2 (0.53) | EGFRERBB3S1PR1MEN1KMT2A | |
| SCHEMBL3229185 | 0.79 | EGFR (0.57) | EGFRERBB3S1PR1CDK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | disclosed |