Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | ESRRG | P62508 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232643 | 0.91 | S1PR1 (0.50) | S1PR1EGFRERBB3MAPTTP53 | |
| SCHEMBL3226072 | 0.90 | EGFR (0.56) | S1PR1EGFRERBB3MAPTLCK | |
| SCHEMBL3231547 | 0.88 | EGFR (0.60) | S1PR1EGFRERBB3MAPTLCK | |
| SCHEMBL3221284 | 0.88 | S1PR1 (0.63) | S1PR1EGFRERBB3LCKKMO | |
| SCHEMBL3228067 | 0.88 | EGFR (0.58) | S1PR1EGFRERBB3LCKKMO | |
| SCHEMBL3222813 | 0.87 | EGFR (0.64) | S1PR1EGFRERBB3LCKKMO | |
| SCHEMBL3232976 | 0.84 | SMN1; SMN2 (0.53) | S1PR1EGFRERBB3MAPTTP53 | |
| SCHEMBL3226692 | 0.83 | TNNI3K (0.56) | S1PR1EGFRERBB3LCKMEN1 | |
| SCHEMBL3225937 | 0.83 | EGFR (0.53) | S1PR1EGFRERBB3LCKKMO | |
| SCHEMBL3226606 | 0.83 | EGFR (0.53) | S1PR1EGFRERBB3LCKKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | disclosed |