Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17950903 | 0.89 | SMYD3 (0.60) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL1316096 | 0.86 | SIGMAR1 (0.69) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL3218381 | 0.86 | SIGMAR1 (0.55) | SMYD3SIGMAR1CHRM3POLBSMN1; SMN2 | |
| SCHEMBL1314827 | 0.85 | SIGMAR1 (0.72) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL1316135 | 0.85 | SIGMAR1 (0.72) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL1317304 | 0.81 | SIGMAR1 (0.67) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL22528193 | 0.79 | SIGMAR1 (0.57) | SMYD3SIGMAR1CHRM3CHRM5GNAI3 | |
| SCHEMBL1314310 | 0.78 | SIGMAR1 (0.51) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL1317967 | 0.77 | SIGMAR1 (0.68) | SMYD3SIGMAR1CHRM3CHRM5RAD52 | |
| SCHEMBL3231838 | 0.76 | HPGD (0.54) | SIGMAR1CHRM3CHRM5GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | MKI67, CCNI, CDK2 | SMYD3 4220/4885SIGMAR1 3905/4885CHRM3 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.