Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.35 |
| ▸ | PIM1 | P11309 | 4/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15808618 | 0.91 | PIM2 (0.41) | MAPTCHRM4KDM4EALDH1A1GLA | |
| SCHEMBL15103598 | 0.91 | CHRM4 (0.39) | MAPTCHRM4KDM4EALDH1A1MEN1 | |
| SCHEMBL1710543 | 0.91 | PIM2 (0.41) | MAPTCHRM4KDM4EALDH1A1GLA | |
| SCHEMBL15103699 | 0.91 | CHRM4 (0.39) | MAPTCHRM4KDM4EALDH1A1MEN1 | |
| SCHEMBL4436044 | 0.91 | CHRM4 (0.39) | MAPTCHRM4KDM4EALDH1A1MEN1 | |
| SCHEMBL11899628 | 0.91 | CHRM4 (0.39) | MAPTCHRM4KDM4EALDH1A1MEN1 | |
| SCHEMBL6526198 | 0.91 | CHRM4 (0.39) | MAPTCHRM4KDM4EALDH1A1MEN1 | |
| SCHEMBL13736950 | 0.91 | PIM2 (0.41) | MAPTCHRM4KDM4EALDH1A1GLA | |
| SCHEMBL15327629 | 0.89 | CHRM4 (0.41) | MAPTCHRM4KDM4EALDH1A1MEN1 | |
| SCHEMBL15327628 | 0.89 | CHRM4 (0.41) | MAPTCHRM4KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026122-A1 | HETEROCYCLIC PIM-KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |