Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.38 |
| ▸ | PIM1 | P11309 | 7/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11899628 | 1.00 | CHRM4 (0.39) | CHRM4MAPTPIM2PIM1PIM3 | |
| SCHEMBL15103699 | 1.00 | CHRM4 (0.39) | CHRM4MAPTPIM2PIM1PIM3 | |
| SCHEMBL15103598 | 1.00 | CHRM4 (0.39) | CHRM4MAPTPIM2PIM1PIM3 | |
| SCHEMBL6526198 | 1.00 | CHRM4 (0.39) | CHRM4MAPTPIM2PIM1PIM3 | |
| SCHEMBL3227034 | 0.91 | MAPT (0.42) | CHRM4MAPTPIM2PIM1PIM3 | |
| SCHEMBL2691577 | 0.87 | PIM2 (0.43) | CHRM4PIM2PIM1PIM3 | |
| SCHEMBL15873228 | 0.87 | PIM2 (0.43) | CHRM4PIM2PIM1PIM3 | |
| SCHEMBL15873466 | 0.87 | PIM2 (0.43) | CHRM4PIM2PIM1PIM3 | |
| SCHEMBL13736950 | 0.86 | PIM2 (0.41) | CHRM4MAPTPIM2PIM1PIM3 | |
| SCHEMBL1710543 | 0.86 | PIM2 (0.41) | CHRM4MAPTPIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-B1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |