Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227025 | 1.00 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1CYP1A2TSHRNFKB1 | |
| SCHEMBL13429102 | 0.89 | HDAC1 (0.47) | ALDH1A1CYP1A2PYGL | |
| Hydrochloric Acid SCHEMBL3224444 | 0.88 | HDAC1 (0.47) | ALDH1A1KMT2AMEN1BLMPMP22 | |
| Hydrochloric Acid SCHEMBL3224470 | 0.88 | HDAC1 (0.47) | ALDH1A1KMT2AMEN1BLMPMP22 | |
| SCHEMBL13428981 | 0.86 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1MAOBKMT2AMEN1 | |
| SCHEMBL8171132 | 0.80 | AKR1C3 (0.39) | ALDH1A1CYP1A2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL13428825 | 0.80 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL13428558 | 0.79 | KDM4E (0.46) | ALDH1A1L3MBTL1KMT2AMEN1MAPT | |
| SCHEMBL13428589 | 0.78 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CYP1A2KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL3227374 | 0.77 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069388-A1 | N-HYDROXYACRYLAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-18 | — | — | US | disclosed |
| EP-2099756-A1 | N-HYDROXYACRYLAMIDE COMPOUNDS | Astellas Pharma Inc. (JP) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008075757-A1 | N-HYDROXYACRYLAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069388-A1 | N-HYDROXYACRYLAMIDE COMPOUNDS | HDAC1, HDAC11, HDAC2 | ALDH1A1 1516/4885L3MBTL1 1127/4885CYP1A2 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.