Known targets — ChEMBL curated mechanism
GRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5
The experimentally established mechanism targets of Tezampanel Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 known ✓ | P42261 | 3/20 | 0.65 |
| ▸ | GRIA2 known ✓ | P42262 | 3/20 | 0.65 |
| ▸ | GRIA3 known ✓ | P42263 | 3/20 | 0.65 |
| ▸ | GRIA4 known ✓ | P48058 | 3/20 | 0.65 |
| ▸ | GRIK1 known ✓ | P39086 | 1/20 | 0.65 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.65 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.65 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.65 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.65 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tezampanel Anhydrous SCHEMBL3677003 | 1.00 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL29227429 | 1.00 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL13320011 | 1.00 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL3688366 | 1.00 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL3688367 | 1.00 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL5508469 | 0.99 | GRIA1 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL14179393 | 0.90 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL2783303 | 0.88 | GRIA2 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8867563 | 0.88 | GRIA2 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL20553364 | 0.88 | GRIA2 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100049284-A1 | USE OF HEAT TO TREAT BIOLOGICAL SYSTEMS EXPOSED TO DAMAGING RADIATION | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 2010-02-25 | — | — | US | disclosed |