Known targets — ChEMBL curated mechanism
GRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5
The experimentally established mechanism targets of Tezampanel Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 known ✓ | P42261 | 3/20 | 0.64 |
| ▸ | GRIA2 known ✓ | P42262 | 3/20 | 0.64 |
| ▸ | GRIA3 known ✓ | P42263 | 3/20 | 0.64 |
| ▸ | GRIA4 known ✓ | P48058 | 3/20 | 0.64 |
| ▸ | GRIK1 known ✓ | P39086 | 1/20 | 0.64 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.64 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.64 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.64 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.64 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tezampanel Anhydrous SCHEMBL3677003 | 0.99 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL13320011 | 0.99 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL3688366 | 0.99 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL3227089 | 0.99 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL3688367 | 0.99 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Tezampanel Anhydrous SCHEMBL29227429 | 0.99 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL14179393 | 0.89 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL2783303 | 0.87 | GRIA2 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8867563 | 0.87 | GRIA2 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL20553364 | 0.87 | GRIA2 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511741-B1 | ESTER DERIVATIVES OF A DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS ANALGESTICS | LILLY CO ELI (US) | 2012-12-26 | — | — | EP | disclosed |
| US-7247644-B2 | Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics | ELI LILLY AND COMPANY (US) | 2007-07-24 | — | — | US | disclosed |
| US-20050256155-A1 | Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | US | disclosed |
| EP-1511741-A1 | ESTER DERIVATIVES OF A DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS ANALGESTICS | ELI LILLY AND COMPANY (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003091243-A1 | ESTER DERIVATIVES OF A DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS ANALGESTICS | ELI LILLY AND COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256155-A1 | Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics | FAAH, FAAH2, GRIK5 | GRIA1 203/4885GRIA2 308/4885GRIA3 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.