Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234097 | 0.91 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3238238 | 0.89 | L3MBTL1 (0.52) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3234191 | 0.88 | HDAC1 (0.46) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3238544 | 0.88 | HDAC3 (0.46) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL1065607 | 0.88 | HDAC1 (0.61) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3242093 | 0.88 | HDAC1 (0.52) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3233819 | 0.82 | HDAC3 (0.47) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3236756 | 0.82 | HDAC1 (0.46) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3232186 | 0.82 | HDAC1 (0.50) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL3238553 | 0.78 | HDAC1 (0.44) | HDAC1HDAC3HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |