Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 18/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.72 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234137 | 0.92 | HDAC3 (0.70) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL3233788 | 0.90 | HDAC1 (0.69) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL3227555 | 0.90 | HDAC1 (0.76) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL3242100 | 0.89 | HDAC1 (0.70) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL7929398 | 0.88 | HDAC1 (0.74) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL3233823 | 0.86 | HDAC3 (0.71) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL3238549 | 0.84 | HDAC1 (0.65) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL2618066 | 0.84 | HDAC1 (0.69) | HDAC3HDAC1NCOR2HDAC2HDAC10 | |
| SCHEMBL528531 | 0.84 | HDAC3 (1.00) | HDAC3HDAC1NCOR2HDAC2HDAC8 | |
| SCHEMBL3238246 | 0.83 | HDAC1 (0.66) | HDAC3HDAC1NCOR2HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |