Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228441 | 0.90 | HDAC3 (0.72) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL3235344 | 0.89 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL3242100 | 0.88 | HDAC1 (0.70) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL3238246 | 0.87 | HDAC1 (0.66) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL3238549 | 0.86 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL3234200 | 0.86 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL1065609 | 0.86 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL30013157 | 0.86 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL8396604 | 0.84 | GAA (0.56) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL14147975 | 0.82 | HDAC1 (0.73) | HDAC1HDAC3HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |