Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | EPRS1 | P07814 | 2/20 | 0.54 |
| ▸ | DHODH | Q02127 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22471898 | 0.90 | AURKA (0.78) | AURKAPOLBPDE10AEPRS1DHODH | |
| SCHEMBL24270274 | 0.89 | AURKA (0.69) | AURKAPOLBPDE10AEPRS1DHODH | |
| SCHEMBL3234823 | 0.86 | AURKA (0.65) | AURKAPOLBPDE10AEPRS1DHODH | |
| SCHEMBL23771105 | 0.85 | AURKA (0.63) | AURKAPOLBPDE10AEPRS1DHODH | |
| SCHEMBL29617660 | 0.85 | AURKA (0.63) | AURKAPDE10AEPRS1DHODHKDM4E | |
| SCHEMBL23590310 | 0.85 | AURKA (0.63) | AURKAPDE10AEPRS1DHODHKDM4E | |
| SCHEMBL24270273 | 0.84 | AURKA (0.62) | AURKAPDE10AEPRS1DHODHKDM4E | |
| SCHEMBL25735926 | 0.82 | AURKA (0.73) | AURKAPDE10AEPRS1DHODHKDM4E | |
| SCHEMBL24686630 | 0.82 | AURKA (1.00) | AURKAPOLBPDE10AEPRS1DHODH | |
| SCHEMBL23590312 | 0.81 | RAB9A (0.68) | AURKAPOLBPDE10AEPRS1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020672-A1 | NOVEL PHENYL-QUINOLINE-CARBOXYLIC ACID PYRIDINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-02-25 | — | — | WO | claimed |
| WO-2010020672-A1 | NOVEL PHENYL-QUINOLINE-CARBOXYLIC ACID PYRIDINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-02-25 | — | — | WO | disclosed |