Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.74 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237764 | 0.85 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL1064518 | 0.85 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL7929398 | 0.85 | HDAC1 (0.74) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL1939096 | 0.83 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL2618066 | 0.81 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL7931728 | 0.80 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3228522 | 0.80 | HDAC3 (0.53) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3235067 | 0.79 | HDAC1 (0.57) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL1937926 | 0.79 | HDAC1 (0.66) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3234137 | 0.79 | HDAC3 (0.70) | HDAC1HDAC3HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |