Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237756 | 0.87 | HDAC3 (0.50) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL1064516 | 0.87 | HDAC4 (0.62) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL3235060 | 0.82 | KDM4E (0.38) | HDAC3HDAC1GAAALDH1A1NPC1 | |
| SCHEMBL3262232 | 0.80 | HDAC1 (0.39) | HDAC3HDAC1HDAC2PKM | |
| SCHEMBL3228530 | 0.80 | HDAC1 (0.74) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL3234097 | 0.78 | HDAC1 (0.48) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL3237174 | 0.78 | HDAC1 (0.41) | HDAC3HDAC1HDAC4HDAC2MEF2D | |
| SCHEMBL3238636 | 0.76 | HDAC3 (0.36) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL3241863 | 0.76 | HDAC1 (0.52) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL3238553 | 0.73 | HDAC1 (0.44) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |