Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.53 |
| ▸ | MTOR | P42345 | 15/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.48 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830198 | 0.90 | MTOR (0.61) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL1830197 | 0.90 | MTOR (0.61) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL15190027 | 0.84 | PIK3CA (0.62) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL442089 | 0.83 | MTOR (0.52) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL15189922 | 0.83 | ATR (0.64) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL2098266 | 0.82 | MTOR (0.65) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL1832533 | 0.82 | MTOR (0.65) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL15189796 | 0.82 | MTOR (0.53) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL3235002 | 0.82 | ATR (0.54) | ATRMTORPIK3CAKCNH2RPTOR | |
| SCHEMBL15190013 | 0.81 | MTOR (0.57) | MTORPIK3CAKCNH2RPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |