Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 6/20 | 0.54 |
| ▸ | MTOR | P42345 | 14/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2097802 | 0.90 | MTOR (0.59) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL1830344 | 0.90 | MTOR (0.59) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL15189922 | 0.89 | ATR (0.64) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL1841030 | 0.87 | MTOR (0.59) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL1841028 | 0.87 | MTOR (0.59) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL3228564 | 0.82 | ATR (0.53) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL1841378 | 0.79 | MTOR (0.60) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL1841380 | 0.79 | MTOR (0.60) | ATRMTORKCNH2PIK3CARPTOR | |
| SCHEMBL15190013 | 0.78 | MTOR (0.57) | MTORKCNH2PIK3CARPTORMLST8 | |
| SCHEMBL3260866 | 0.78 | MTOR (0.57) | MTORKCNH2PIK3CARPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | claimed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |