Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233811 | 0.91 | CHRM1 (0.47) | CHRM1P2RX7MAPTGAAPTGDR2 | |
| SCHEMBL3234252 | 0.88 | CHRM1 (0.44) | CHRM1P2RX7MAPTPTGDR2TP53 | |
| SCHEMBL3234223 | 0.86 | CHRM1 (0.47) | CHRM1P2RX7MAPTPTGDR2TP53 | |
| SCHEMBL3228651 | 0.85 | CHRM1 (0.64) | CHRM1MAPTTP53RXFP1 | |
| SCHEMBL3234555 | 0.85 | CHRM1 (0.49) | CHRM1P2RX7MAPTPTGDR2TP53 | |
| SCHEMBL3230518 | 0.84 | CHRM1 (0.48) | CHRM1MAPTGAAPTGDR2TP53 | |
| SCHEMBL3234268 | 0.84 | CHRM1 (0.54) | CHRM1P2RX7MAPTGAATP53 | |
| SCHEMBL3239684 | 0.84 | CHRM1 (0.52) | CHRM1P2RX7MAPTPTGDR2ROCK2 | |
| SCHEMBL3234589 | 0.83 | CHRM1 (0.55) | CHRM1P2RX7MAPTTP53SMN1; SMN2 | |
| SCHEMBL3234399 | 0.83 | CHRM1 (0.63) | CHRM1MAPTTP53CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |