Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230518 | 0.93 | CHRM1 (0.48) | CHRM1PTGDR2PDE4APDE7AMAPT | |
| SCHEMBL3230300 | 0.93 | CHRM1 (0.48) | CHRM1PTGDR2PDE4APDE7AMAPT | |
| SCHEMBL3238408 | 0.90 | CHRM1 (0.46) | CHRM1 | |
| SCHEMBL3234399 | 0.89 | CHRM1 (0.63) | CHRM1MAPTLMNA | |
| SCHEMBL3234555 | 0.87 | CHRM1 (0.49) | CHRM1PTGDR2MAPTP2RX7 | |
| SCHEMBL3238090 | 0.86 | CHRM1 (0.46) | CHRM1PTGDR2PDE4APDE7ALMNA | |
| SCHEMBL3237961 | 0.86 | CHRM1 (0.54) | CHRM1MAPTLMNAP2RX7 | |
| SCHEMBL3234268 | 0.86 | CHRM1 (0.54) | CHRM1MAPTP2RX7 | |
| SCHEMBL3234223 | 0.85 | CHRM1 (0.47) | CHRM1PTGDR2MAPTP2RX7 | |
| SCHEMBL2489039 | 0.85 | CHRM1 (0.74) | CHRM1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |