Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235749 | 0.93 | CSNK1D (0.38) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL2848948 | 0.83 | CSNK1D (0.39) | CSNK1DMAPK14CSNK1E | |
| SCHEMBL3230997 | 0.70 | MAPK14 (0.42) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL3228998 | 0.67 | CSNK1D (0.40) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL5091901 | 0.66 | MAPK14 (0.52) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL3233018 | 0.64 | MAPK14 (0.43) | CSNK1DMAPK14CSNK1EMAPK13MAPK12 | |
| SCHEMBL5452499 | 0.64 | CSNK1D (0.60) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL5850112 | 0.63 | MAP4K4 (0.64) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL3235753 | 0.61 | MAPK14 (0.35) | CSNK1DMAP4K4MAPK9CSNK1A1MAP4K5 | |
| SCHEMBL2849352 | 0.59 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069436-A1 | IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT | Merckle (DE) | 2010-03-18 | — | — | US | disclosed |
| EP-2054404-A1 | IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT | MERCKLE GMBH (DE) | 2009-05-06 | — | — | EP | disclosed |
| EP-1894925-A1 | Imidazole compounds having an antiinflammatory effect | MERCKLE GMBH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2008023066-A1 | IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT | MERCKLE GMBH (DE) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069436-A1 | IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT | MIF, TNF, IL1B | CSNK1D 2157/4885MAP4K4 1494/4885MAPK9 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.