Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 5/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.56 |
| ▸ | ADK | P55263 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | PNP | P00491 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2'-Deoxytubercidin SCHEMBL5918784 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL7872096 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL13314431 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL7872094 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL23982116 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL14104716 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL23982321 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL14294692 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| 2'-Deoxytubercidin SCHEMBL5918830 | 1.00 | METTL3 (0.57) | METTL3PRMT5ADKHIF1APNP | |
| SCHEMBL21625244 | 0.91 | METTL3 (0.60) | METTL3PRMT5ADKADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399588-A1 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | Merck Sharp & Dohme Corp. (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2360166-A1 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | Merck Sharp & Dohme Corp. (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20100286235-A1 | METHODS FOR INCREASING IN VIVO EFFICACY OF OLIGONUCLEOTIDES AND INHIBITING INFLAMMATION IN MAMMALS | TOPIGEN PHARMACEUTIQUE INC. (CA) | 2010-11-11 | — | — | US | disclosed |
| US-7745420-B2 | Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals | TOPIGEN PHARMACEUTIQUE, INC. (CA) | 2010-06-29 | — | — | US | disclosed |
| EP-1406667-B1 | METHODS FOR INCREASING IN VIVO EFFICACY OF OLIGONUCLEOTIDES AND INHIBITING INFLAMMATION IN MAMMALS | TOPIGEN PHARMACEUTICALS INC (CA) | 2008-02-20 | — | — | EP | disclosed |
| US-20050032723-A1 | Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals | PHARMAXIS LTD (AU) | 2005-02-10 | — | — | US | disclosed |
| EP-1406667-A2 | METHODS FOR INCREASING i IN VIVO /i EFFICACY OF OLIGONUCLEOTIDES AND INHIBITING INFLAMMATION IN MAMMALS | Topigen Pharmaceutiques Inc (CA) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004511-A2 | METHODS FOR INCREASING IN VIVO EFFICACY OF OLIGONUCLEOTIDES AND INHIBITING INFLAMMATION IN MAMMALS | TOPIGEN PHARMACEUTIQUE INC.. (CA) | 2003-01-16 | — | — | WO | disclosed |