Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 12/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.45 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935790 | 0.83 | PIK3CD (0.60) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| SCHEMBL29903062 | 0.80 | JAK2 (0.57) | PIK3CGPIK3CDPIK3CAPAK4JAK1 | |
| SCHEMBL12909575 | 0.79 | DHFR (0.51) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| Hydrochloric Acid SCHEMBL937520 | 0.78 | DHFR (0.50) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| SCHEMBL20641333 | 0.75 | PIK3CG (0.44) | PIK3CGPIK3CDKDM4EPIK3CAPAK4 | |
| SCHEMBL937347 | 0.74 | PDE10A (0.51) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| SCHEMBL25440285 | 0.74 | PIK3CG (0.40) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| SCHEMBL29497987 | 0.74 | PIK3CG (0.40) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| SCHEMBL936518 | 0.74 | PIK3CG (0.51) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA | |
| SCHEMBL936333 | 0.74 | PIK3CG (0.51) | PIK3CGPIK3CDKDM4EHSD17B10PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007100-A1 | 7-SUBSTITUTED AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2010-01-21 | — | — | WO | claimed |
| WO-2010007100-A1 | 7-SUBSTITUTED AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007100-A1 | 7-SUBSTITUTED AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2010-01-21 | — | — | WO | disclosed |