Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1701610 | 0.85 | PTPN1 (0.52) | PTPN1MAOBHTTKDM4EMEN1 | |
| SCHEMBL13427763 | 0.83 | KLKB1 (0.53) | PTPN1MAOBHTTKDM4EMEN1 | |
| SCHEMBL2099037 | 0.82 | CES2 (0.61) | PTPN1MEN1KMT2AMAPTHPGD | |
| SCHEMBL6818999 | 0.81 | MAOB (0.45) | MAOBHTTKDM4EMEN1KMT2A | |
| SCHEMBL11314160 | 0.81 | HSP90AB1 (0.52) | MAOBHTTKDM4EMEN1KMT2A | |
| SCHEMBL18797551 | 0.81 | PTPN1 (0.52) | PTPN1MAPTTP53ALDH1A1CES2 | |
| SCHEMBL3854857 | 0.80 | CA12 (0.57) | PTPN1MAPTNPC1ALOX12RAB9A | |
| SCHEMBL9115906 | 0.80 | NPC1 (0.47) | PTPN1MAOBHTTKDM4EMEN1 | |
| SCHEMBL3920988 | 0.79 | PTPN1 (0.50) | PTPN1MAPTNPC1HPGDRAB9A | |
| SCHEMBL3924529 | 0.79 | PTPN1 (0.50) | PTPN1MEN1KMT2AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| US-6737434-B2 | HAVING ACTIVITIES ANALOGOUS TO THOSE EXHIBITED BY GRANULOCYTE-COLONY STIMULATING FACTOR; FOR THERAPY OF IMMUNE DISEASES WHICH ACCOMPANY REDUCTION IN NEUTROPHILS CAUSED BY CHEMOTHERAPY OR RADIOTHERAPY OF CANCER | SSP CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| US-20030176482-A1 | Imidazole derivatives or their salts | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2003-09-18 | — | — | US | disclosed |
| EP-1319658-A1 | IMIDAZOLE DERIVATIVES OR THEIR SALTS | SSP Co., Ltd. (JP) | 2003-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176482-A1 | Imidazole derivatives or their salts | CSF3R, CSF1R, FLT3 | PTPN1 2564/4885MAOB 2734/4885HTT 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.