Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116963 | 0.88 | CYP2C19 (0.41) | P2RX7CYP2C19HSP90AB1KDM4EKCNH2 | |
| SCHEMBL19547099 | 0.81 | P2RX7 (0.42) | P2RX7HSP90AB1ADORA2AADORA1 | |
| SCHEMBL3264705 | 0.79 | ADORA1 (0.49) | KDM4EADORA1 | |
| SCHEMBL1497102 | 0.78 | DPP4 (0.39) | P2RX7 | |
| SCHEMBL21315012 | 0.78 | GAA (0.33) | P2RX7KDM4E | |
| SCHEMBL29057189 | 0.74 | P2RX7 (0.39) | P2RX7HSP90AB1ADORA2AADORA1 | |
| SCHEMBL1497228 | 0.73 | P2RX7 (0.42) | P2RX7 | |
| SCHEMBL23412929 | 0.72 | GRM5 (0.42) | P2RX7KDM4EDHFR | |
| SCHEMBL3241010 | 0.71 | P2RX7 (0.34) | P2RX7HSP90AB1 | |
| SCHEMBL12497599 | 0.71 | HSP90AB1 (0.47) | HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209775-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB Pharma, S.A. (BE) | 2010-07-28 | — | — | EP | claimed |
| WO-2009047255-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB PHARMA, S.A. (BE) | 2009-04-16 | — | — | WO | claimed |
| EP-2209775-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB Pharma, S.A. (BE) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009047255-A1 | HETEROBICYCLIC COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS | UCB PHARMA, S.A. (BE) | 2009-04-16 | — | — | WO | disclosed |