Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230243 | 0.78 | PPARA (0.54) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL19380041 | 0.78 | TSHR (0.59) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL23747359 | 0.77 | CNR1 (0.61) | SMN1; SMN2NPC1RAB9AHTTPOLB | |
| SCHEMBL5333738 | 0.77 | TSHR (0.66) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL1680760 | 0.77 | CYSLTR1 (0.52) | SMN1; SMN2POLBKMT2AMEN1HPGD | |
| SCHEMBL11626210 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL1574010 | 0.76 | MAPK14 (0.64) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11623709 | 0.75 | SMN1; SMN2 (0.69) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL3230417 | 0.74 | RAB9A (0.62) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL11626590 | 0.74 | POLB (0.74) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334637-B1 | NOVEL POTASSIUM CHANNEL BLOCKERS | JAPAN TOBACCO INC (JP) | 2017-01-04 | — | — | EP | disclosed |
| US-8372840-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2013-02-12 | — | — | US | disclosed |
| US-20100087438-A1 | New Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| WO-2010023446-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087438-A1 | New Potassium Channel Blockers | KCNJ2, KCNB1, KCNJ11 | SMN1; SMN2 3819/4885NPC1 511/4885RAB9A 1126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.