Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | CNR2 | P34972 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30497877 | 0.87 | POLB (0.78) | TP53LMNACNR2CHRM1POLB | |
| SCHEMBL9028399 | 0.87 | LMNA (1.00) | TP53LMNACNR2CHRM1 | |
| SCHEMBL31554247 | 0.87 | LMNA (1.00) | TP53LMNACNR2CHRM1 | |
| SCHEMBL2932309 | 0.85 | POLB (0.83) | TP53LMNACNR2CHRM1POLB | |
| SCHEMBL3241260 | 0.85 | TP53 (0.68) | TP53LMNACNR2CHRM1POLB | |
| SCHEMBL3228550 | 0.85 | LMNA (0.84) | TP53LMNACNR2CHRM1 | |
| SCHEMBL3234154 | 0.85 | LMNA (0.89) | TP53LMNACNR2CHRM1 | |
| SCHEMBL2487513 | 0.85 | LMNA (0.84) | TP53LMNACNR2CHRM1 | |
| SCHEMBL16341623 | 0.84 | LMNA (0.82) | TP53LMNACNR2CHRM1 | |
| SCHEMBL2489417 | 0.82 | LMNA (0.64) | TP53LMNACNR2CHRM1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |