Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230348 | 0.92 | CHRM1 (0.72) | CHRM1MAPTLMNA | |
| SCHEMBL3234264 | 0.88 | CHRM1 (0.73) | CHRM1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL3233806 | 0.86 | CHRM1 (0.64) | CHRM1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL3230296 | 0.85 | CHRM1 (0.66) | CHRM1MAPTLMNA | |
| SCHEMBL3230518 | 0.85 | CHRM1 (0.48) | CHRM1MAPTSMN1; SMN2TP53 | |
| SCHEMBL3234394 | 0.84 | CHRM1 (0.86) | CHRM1MAPTLMNATP53 | |
| SCHEMBL3228651 | 0.83 | CHRM1 (0.64) | CHRM1MAPTLMNATP53 | |
| SCHEMBL3237954 | 0.83 | CHRM1 (0.73) | CHRM1MAPTLMNA | |
| SCHEMBL14747460 | 0.82 | CHRM1 (0.72) | CHRM1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL3237079 | 0.82 | CHRM1 (0.62) | CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |