Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914913 | 0.83 | ADORA2A (0.48) | GABRG2GABRB3GABRA5GABRA3ALDH1A1 | |
| SCHEMBL565466 | 0.82 | ESR2 (0.50) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL19194059 | 0.80 | GABRG2 (0.55) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL30683491 | 0.80 | GABRG2 (0.55) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL18411313 | 0.75 | ESR2 (0.47) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL27365154 | 0.75 | ESR2 (0.47) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL31663516 | 0.75 | ESR2 (0.47) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL25774471 | 0.75 | ESR2 (0.45) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL18411431 | 0.75 | ESR2 (0.50) | GABRG2GABRB3GABRA5GABRA3ESR2 | |
| SCHEMBL12679751 | 0.72 | GABRG2 (0.43) | GABRG2GABRB3GABRA5GABRA3ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590951-A1 | BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS | Pfizer Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004743-A1 | BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-01-12 | — | — | WO | disclosed |