Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | GUCY1B2 | O75343 | 4/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 4/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 4/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222749 | 0.88 | SMN1; SMN2 (0.43) | RAB9ASMN1; SMN2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3237582 | 0.85 | GUCY1B2 (0.42) | RAB9ASMN1; SMN2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3229972 | 0.83 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2MAPTGUCY1B2GUCY1A2 | |
| SCHEMBL3222823 | 0.81 | GUCY1B2 (0.46) | RAB9ASMN1; SMN2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3230866 | 0.81 | GUCY1B2 (0.46) | RAB9ASMN1; SMN2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3229063 | 0.80 | GUCY1B2 (0.45) | RAB9ASMN1; SMN2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3235305 | 0.79 | SMN1; SMN2 (0.54) | RAB9ASMN1; SMN2MAPTGUCY1B2GUCY1A2 | |
| SCHEMBL3237560 | 0.79 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2MAPTNPC1L3MBTL1 | |
| SCHEMBL21206043 | 0.78 | SMN1; SMN2 (0.81) | RAB9ASMN1; SMN2MAPTNPC1L3MBTL1 | |
| SCHEMBL3229812 | 0.78 | MAPT (0.51) | RAB9ASMN1; SMN2MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |